|
KMID : 0617919890060010007
|
|
Wonkwang Oriental Medicine
1989 Volume.6 No. 1 p.7 ~ p.29
|
|
|
Effects of Dochaetang Extract on the gastro-intestinal function and several intestinal beaterials
|
|
|
|
|
Abstract
|
|
|
In order to grasp the nature Dochaetang effects of Dochaetang on the intestinal movement of rabbit, the transport faculty of meal in small intestine of rat, experimental gastric and duodenal ulcers in rat, and the several intestinal bacterias were investigated by using its water and methanol extract.
Dochaetang water extract(DWE) and methanol extract(DME) exhibited the contractile response and augmentation of spontaneous movement in the longitudinal muscle strips of jejunum, ileum and colon also circular muscle strip of colon, which were isolated from rabbits.
Augmentation of spontaneous movement and contractile response of jejunum and ileum strips to DWE and DME were inhibited by cyproheptadine or diphenhydramine, but not affected by Ca^+2 free in bath solution.
Atropine suppressed the above contractile response, but did not effect the augmentation of spontaneous movement.
Atropine markedly decreased the spontaneous movement and contractile respone of longitudinal and circular muscle strips of colon to DWE or DME however cyproheptadine showed a significant inhibition on above two actions of longitudinal muscle strip, no remarkable effect on the two actions of circular muscle strip, and them diphenhydramine inhibited the two actions of longitudinal muscle strip and contractile response of circular muscle strip, but had no effect on the augmentation of spontaneous movement of circular muscle strips of colon to DWE and DME.
Ca^+2 free in bath solution did not affect the all actions of longitudinal and circular muscle strips of colon to DWE and DME.
DME given orally exhibited a significant increase of transport rate of charcoal meal in digestive organs of rat.
DWE(p.o) potently inhibited the development of indomethacin of serotonin induced gastric ulcers and histamine-Carbachol induced doudenal ulcers in rats.
DWE showed antibacterial activity against several intestinal bacteria in vitro test.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|